1. (noun) city in the northern Dominican Republic

• santiago de los caballeros

2. (noun) a port city in southeastern Cuba; industrial center

• santiago de cuba

3. (noun) the capital and largest city of Chile; located in central Chile; one of the largest cities in South America

• capital of chile
• gran santiago
• santiago de chile

4. (noun) a naval battle in the Spanish-American War (1898); the United States fleet bottled up the Spanish ships in the harbor of Santiago de Cuba and destroyed them when they tried to escape

• santiago de cuba