1. (noun) something or someone that causes trouble; a source of unhappiness

• annoyance
• bother
• botheration
• infliction
• pain
• pain in the neck

1. (noun) something or someone that causes trouble; a source of unhappiness

• irritant
• thorn
• nuisance
• plague

1. (noun) something or someone that causes trouble; a source of unhappiness

• negative stimulus

1. (noun) something or someone that causes trouble; a source of unhappiness

• anguish
• hurt
• pain
• annoy
• annoy
• bother
• bother
• chafe
• chafe
• devil
• devil
• get at
• get at
• get to
• get to
• gravel
• gravel
• irritate
• irritate
• nark
• nark
• nettle
• nettle
• rag
• rag
• rile
• rile
• vex
• vex
• bother
• bother
• discommode
• disoblige
• incommode
• inconvenience
• put out
• trouble